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Conformational Dynamics and Antigenicity in the Disordered Malaria Antigen Merozoite Surface Protein 2

5 Mar 2015

Abstract excerpt

Merozoite surface protein 2 (MSP2) of Plasmodium falciparum is an abundant, intrinsically disordered protein that is GPI-anchored to the surface of the invasive blood stage of the malaria parasite. Recombinant MSP2 has been trialled as a component of a malaria vaccine, and is one of several disordered proteins that are candidates for inclusion in vaccines for malaria and other diseases. Nonetheless, little is...

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PMID: 25742002
DOI: 10.1371/journal.pone.0119899

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