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Article

Interactions between paraoxonase 1 genetic polymorphisms and smoking and their effects on oxidative stress and lung cancer risk in a Korean population.

PloS one - 1 Jan 2015

Eom Sang-Yong, Yim Dong-Hyuk, Lee Chul-Ho, Choe Kang-Hyeon, An Jin Young, Lee Kye Young, Kim Yong-Dae, Kim Heon

Abstract excerpt

BACKGROUND: Few studies in epidemiology have evaluated the effects of gene-environment interaction on oxidative stress, even though this interaction is an important etiologic factor in lung carcinogenesis. We investigated the effects of the genetic polymorphisms of paraoxonase 1 (PON1), smoking, and the interaction between the two on lung cancer risk and oxidative stress. METHODS: This study's subjects consisted...

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Source

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Identifiers

PMID: 25741997
DOI: 10.1371/journal.pone.0119100
PMCID: PMC4350985

Genes

PON1

Provenance

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