Article
The membrane protein PrsS mimics σS in protecting Staphylococcus aureus against cell wall-targeting antibiotics and DNA-damaging agents.
Microbiology (Reading, England) - 1 May 2015
Krute Christina N, Bell-Temin Harris, Miller Halie K, Rivera Frances E, Weiss Andy, Stevens Stanley M, Shaw Lindsey N
Abstract excerpt
Staphylococcus aureus possesses a lone extracytoplasmic function (ECF) sigma factor, σ(S). In Bacillus subtilis, the ECF sigma factor, σ(W), is activated through a proteolytic cascade that begins with cleavage of the RsiW anti-sigma factor by a site-1 protease (S1P), PrsW. We have identified a PrsW homologue in S. aureus (termed PrsS) and explored its role in σ(S) regulation. Herein, we demonstrate that although...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.