Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis.

doi:10.1093/neuonc/nov027

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Article

Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis.

Neuro-oncology - 1 Oct 2015

Erson-Omay E Zeynep, Çağlayan Ahmet Okay, Schultz Nikolaus, Weinhold Nils, Omay S Bülent, Özduman Koray, Köksal Yavuz, Li Jie, Serin Harmancı Akdes, Clark Victoria, Carrión-Grant Geneive, Baranoski Jacob, Çağlar Caner, Barak Tanyeri, Coşkun Süleyman, Baran Burçin, Köse Doğan, Sun Jia, Bakırcıoğlu Mehmet, Moliterno Günel Jennifer, Pamir M Necmettin, Mishra-Gorur Ketu, Bilguvar Kaya, Yasuno Katsuhito, Vortmeyer Alexander, Huttner Anita J, Sander Chris, Günel Murat

Abstract excerpt

BACKGROUND: Malignant high-grade gliomas (HGGs), including the most aggressive form, glioblastoma multiforme, show significant clinical and genomic heterogeneity. Despite recent advances, the overall survival of HGGs and their response to treatment remain poor. In order to gain further insight into disease pathophysiology by correlating genomic landscape with clinical behavior, thereby identifying distinct HGG...

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PMID: 25740784
DOI: 10.1093/neuonc/nov027
PMCID: PMC4578578

Genes

POLE
MSH6

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