Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adenylate kinase 2 links mitochondrial energy metabolism to the induction of the unfolded protein response.

The Journal of biological chemistry - 11 Feb 2011

Burkart Alison, Shi Xiarong, Chouinard My, Corvera Silvia

Abstract excerpt

The unfolded protein response (UPR) is a homeostatic signaling mechanism that balances the protein folding capacity of the endoplasmic reticulum (ER) with the secretory protein load of the cell. ER protein folding capacity is dependent on the abundance of chaperones, which is increased in response to UPR signaling, and on a sufficient ATP supply for their activity. An essential branch of the UPR entails the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3-L1 Cells
Share to Adenylate Kinase
Share to Leukopenia

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Plasma Cells

Share to Regulatory Factor X Transcription Factors

Share to Severe Combined Immunodeficiency

Share to Unfolded Protein Response

Share to X-Box Binding Protein 1

Source

Open in PubMed Open full text

Identifiers

PMID: 20876536
DOI: 10.1074/jbc.M110.134106
PMCID: PMC3039340

Genes

XBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adenylate kinase 2 links mitochondrial energy metabolism to the induction of the unfolded protein response.PMID 20876536Read ↗

Reticular dysgenesis–associated AK2 protects hematopoietic stem and progenitor cell development from oxidative stressSemantic proximity Read ↗

KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein ResponseSemantic proximity Read ↗

Reticular dysgenesis (aleukocytosis) is caused by mutations in the gene encoding mitochondrial adenylate kinase 2.Semantic proximity Read ↗

AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages.Semantic proximity Read ↗

Reticular Dysgenesis and Mitochondriopathy Induced by Adenylate Kinase 2 Deficiency with Atypical Presentation.Semantic proximity Read ↗

Creld2 function during unfolded protein response is essential for liver metabolism homeostasisSemantic proximity Read ↗

The Effect of Heterozygous Mutation of Adenylate Kinase 2 Gene on Neutrophil Differentiation.Semantic proximity Read ↗

The IRE1α-XBP1 Pathway of the Unfolded Protein Response Is Required for AdipogenesisSemantic proximity Read ↗

ATM-associated signalling triggers the unfolded protein response and cell death in response to stressSemantic proximity Read ↗

Involvement of the IRE1α-XBP1 Pathway and XBP1s-Dependent Transcriptional Reprogramming in Metabolic DiseasesSemantic proximity Read ↗

RSAD2/VIPERIN and CMPK2 Coordinate an Immunometabolic Response to Epstein-Barr VirusSemantic proximity Read ↗

Reticular Dysgenesis-associated Adenylate Kinase 2 deficiency causes failure of myelopoiesis through disordered purine metabolismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.