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Article

Adenylate kinase 2 links mitochondrial energy metabolism to the induction of the unfolded protein response.

The Journal of biological chemistry - 11 Feb 2011

Burkart Alison, Shi Xiarong, Chouinard My, Corvera Silvia

Abstract excerpt

The unfolded protein response (UPR) is a homeostatic signaling mechanism that balances the protein folding capacity of the endoplasmic reticulum (ER) with the secretory protein load of the cell. ER protein folding capacity is dependent on the abundance of chaperones, which is increased in respons...

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Identifiers

PMID: 20876536
DOI: 10.1074/jbc.M110.134106
PMCID: PMC3039340

Genes

XBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20876536-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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