Article
A nonsense nucleotide substitution in the oculocutaneous albinism II gene underlies the original pink-eyed dilution allele (Oca2(p)) in mice.
Experimental animals - 1 Jan 2015
Shoji Haruka, Kiniwa Yukiko, Okuyama Ryuhei, Yang Mu, Higuchi Keiichi, Mori Masayuki
Abstract excerpt
The original pink-eyed dilution (p) on chromosome 7 is a very old spontaneous mutation in mice. The oculocutaneous albinism II (Oca2) gene has previously been identified as the p gene. Oca2 transcripts have been shown to be absent in the skin of SJL/J mice with the original p mutant allele (Oca2(p)); however, the molecular genetic lesion underlying the original Oca2(p) allele has never been reported. The NCT...
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