Article
Polygenic control of the wavy coat of the NCT mouse: involvement of an intracisternal A particle insertional mutation of the protease, serine 53 (Prss53) gene, and a modifier gene.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Sept 2022
Mori Masayuki, Liu Chang, Yoshizawa Takahiro, Miyahara Hiroki, Dai Jian, Igarashi Yuichi, Cui Xiaoran, Li Ying, Kang Xiaojing, Higuchi Keiichi
Abstract excerpt
The Nakano cataract mouse (NCT) manifests a wavy coat for their first hair as a genetic trait. In this study, we explored the molecular genetic basis of the wavy coat. We revealed by crossing experiments that the wavy coat is controlled by a major gene on chromosome 7 of NCT, homozygosity of which is a prerequisite for developing the wavy coat, and by a gene on chromosome 9 with a minor effect to reinforce the...
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