Article
Establishment of a novel dwarf rat strain: cartilage calcification insufficient (CCI) rats.
Experimental animals - 1 Jan 2015
Tanaka Masami, Watanabe Minoru, Yokomi Izuru, Matsumoto Naoki, Sudo Katsuko, Satoh Hitoshi, Igarashi Tsuneo, Seki Azusa, Amano Hitoshi, Ohura Kiyoshi, Ryu Kakei, Shibata Shunichi, Nagayama Motohiko, Tanuma Jun-ichi
Abstract excerpt
Rats with dwarfism accompanied by skeletal abnormalities, such as shortness of the limbs, tail, and body (dwarf rats), emerged in a Jcl-derived Sprague-Dawley rat colony maintained at the Institute for Animal Experimentation, St. Marianna University Graduate School of Medicine. Since the dwarfism was assumed to be due to a genetic mutation based on its frequency, we bred the dwarf rats and investigated their...
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