Article
A new neurological mutant rat with symmetrical calcification of Purkinje cells in cerebellum.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) - 1 Sept 1999
Ando Y, Ichihara N, Takeshita S, Nagata M, Kimura T, Tanase H, Kikuchi T
Abstract excerpt
A new neurological mutant has been found in the inbred F344 strain of rats. The mutation is inherited as an autosomal recessive trait and is manifest clinically by a hesitant and wobbling gait with asynergic limbs and slight tremor. These symptoms begin at 16-18 days of age and remain essentially constant thereafter. Histologic examination revealed severe degeneration of the Purkinje cells and symmetrical...
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