Article
Knockdown of myorg leads to brain calcification in zebrafish.
Molecular brain - 23 Jul 2022
Zhao Miao, Lin Xiao-Hong, Zeng Yi-Heng, Su Hui-Zhen, Wang Chong, Yang Kang, Chen Yi-Kun, Lin Bi-Wei, Yao Xiang-Ping, Chen Wan-Jin
Abstract excerpt
Primary familial brain calcification (PFBC) is a neurogenetic disorder characterized by bilateral calcified deposits in the brain. We previously identified that MYORG as the first pathogenic gene for autosomal recessive PFBC, and established a Myorg-KO mouse model. However, Myorg-KO mice developed brain calcifications until nine months of age, which limits their utility as a facile PFBC model system. Hence,...
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