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Article

Diversity and selectivity in mRNA translation on the endoplasmic reticulum.

Nature reviews. Molecular cell biology - 1 Apr 2015

Reid David W, Nicchitta Christopher V

Abstract excerpt

Pioneering electron microscopy studies defined two primary populations of ribosomes in eukaryotic cells: one freely dispersed through the cytoplasm and the other bound to the surface of the endoplasmic reticulum (ER). Subsequent investigations revealed a specialized function for each population, with secretory and integral membrane protein-encoding mRNAs translated on ER-bound ribosomes, and cytosolic protein...

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PMID: 25735911
DOI: 10.1038/nrm3958
PMCID: PMC4494666

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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