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Article

Mutation of a single residue in the ba3 oxidase specifically impairs protonation of the pump site.

Proceedings of the National Academy of Sciences of the United States of America - 17 Mar 2015

von Ballmoos Christoph, Gonska Nathalie, Lachmann Peter, Gennis Robert B, Ädelroth Pia, Brzezinski Peter

Abstract excerpt

The ba3-type cytochrome c oxidase from Thermus thermophilus is a membrane-bound protein complex that couples electron transfer to O2 to proton translocation across the membrane. To elucidate the mechanism of the redox-driven proton pumping, we investigated the kinetics of electron and proton transfer in a structural variant of the ba3 oxidase where a putative "pump site" was modified by replacement of Asp372 by...

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Source

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Identifiers

PMID: 25733886
DOI: 10.1073/pnas.1422434112
PMCID: PMC4371939

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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