Article
Modeling the specific CD4+ T cell response against a tumor neoantigen.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2015
Flament Héloïse, Alonso Ramirez Ruby, Prémel Virginie, Joncker Nathalie T, Jacquet Alexandra, Scholl Suzy, Lantz Olivier
Abstract excerpt
The antitumor activity of CD4(+) T cells is increasingly acknowledged in both humans and mice. The involved mechanisms have been mostly studied using transplanted tumor mouse systems. In these models, many tumor cells die at the time of implantation leading to the release of Ag in an inflammatory context contrasting with the slow and nondestructive growth of early-stage human tumors. In this study, we show that...
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