Article
A novel thymoma-associated immunodeficiency with increased naive T cells and reduced CD247 expression.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2015
Christopoulos Petros, Dopfer Elaine P, Malkovsky Miroslav, Esser Philipp R, Schaefer Hans-Eckart, Marx Alexander, Kock Sylvia, Rupp Nicole, Lorenz Myriam R, Schwarz Klaus, Harder Jan, Martin Stefan F, Werner Martin, Bogdan Christian, Schamel Wolfgang W A, Fisch Paul
Abstract excerpt
The mechanisms underlying thymoma-associated immunodeficiency are largely unknown, and the significance of increased blood γδ Τ cells often remains elusive. In this study we address these questions based on an index patient with thymoma, chronic visceral leishmaniasis, myasthenia gravis, and a marked increase of rare γδ T cell subsets in the peripheral blood. This patient showed cutaneous anergy, even though he...
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