Article

Thymoma associated Good syndrome presenting with combined immunodeficiency severe neutropenia and opportunistic infection

2026-05-27

Abstract excerpt

<title>Abstract</title> <p>Background: Thymomas can disrupt normal thymopoiesis through reduced expression of the autoimmune regulator (AIRE) gene, leading to immune dysregulation and paraneoplastic syndromes such as Good's syndrome. This rare condition is characterized by hypogammaglobulinemia, profound B-cell lymphopenia, T-cell dysfunction, neutralizing autoantibodies against cytokines such as interferon-α and...

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Literature Corpus work: d916bcd0-e401-56e4-bad4-8bf75f15b903
DOI: 10.21203/rs.3.rs-9164396/v1

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