Article

Targeting 14-3-3ζ overcomes resistance to EGFR-TKI in lung adenocarcinoma via BMP2/Smad/ID-1 signaling

2020-02-17

Abstract excerpt

<title>Abstract</title> <p>Background: 14-3-3ζ protein which acts as a putative oncoprotein has been found to promote proliferation, metastasis and chemoresistance of cancer cells in several cancers including lung adenocarcinoma (LUAD), however, its significance in epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) resistance remains unknown. <h4>Methods:</h4> The Cancer Genome Atlas (TCGA) dat...

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Literature Corpus work: f3ca6e4f-ac3d-5506-953b-e826df2cee4f
DOI: 10.21203/rs.2.23664/v1

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