Establishment and characterization of a panel of human uveal melanoma xenografts derived from primary and/or metastatic tumors.

doi:10.1158/1078-0432.CCR-09-3066

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Article

Establishment and characterization of a panel of human uveal melanoma xenografts derived from primary and/or metastatic tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2010

Némati Fariba, Sastre-Garau Xavier, Laurent Cécile, Couturier Jérôme, Mariani Pascale, Desjardins Laurence, Piperno-Neumann Sophie, Lantz Olivier, Asselain Bernard, Plancher Corine, Robert Delphine, Péguillet Isabelle, Donnadieu Marie-Hélène, Dahmani Ahmed, Bessard Marie-Andrée, Gentien David, Reyes Cécile, Saule Simon, Barillot Emmanuel, Roman-Roman Sergio, Decaudin Didier

Abstract excerpt

PURPOSE: Uveal melanoma is the most common primary intraocular malignant tumor in adults and is defined by a poor natural outcome, as 50% of patients die from metastases. The aim of this study was to develop and characterize a panel of human uveal melanoma xenografts transplanted into immunodeficient mice. EXPERIMENTAL DESIGN: Ninety tumor specimens were grafted into severe combined immunodeficient mice, and 25...

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PMID: 20371695
DOI: 10.1158/1078-0432.CCR-09-3066

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