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Article

Combination of Matrine and Sorafenib Decreases the Aggressive Phenotypes of Hepatocellular Carcinoma Cells.

Chemotherapy - 1 Jan 2014

Lin Yan, Lin Lianjie, Jin Yu, Zhang Ying, Wang Dongxu, Tan Yue, Zheng Changqing

Abstract excerpt

BACKGROUND: The aim of this study was to determine the effects of matrine (a natural alkaloid) on sorafenib-induced cytotoxicity against hepatocellular carcinoma (HCC) cells, and to explore the molecular mechanisms involved. METHODS: HepG2 and Hep3B cells were treated with matrine alone or in combination with sorafenib, and cell viability and apoptosis were assessed. The involvement of micro (mi)RNA-21 in the...

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Identifiers

PMID: 25721136
DOI: 10.1159/000371736

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PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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