Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

mTOR inhibition sensitizes human hepatocellular carcinoma cells to resminostat.

Biochemical and biophysical research communications - 2 Sept 2016

Peng Xingang, Zhang Donghui, Li Zhengling, Fu Meili, Liu Haiyan

Abstract excerpt

Histone deacetylases (HDACs) hyper-activity in hepatocellular carcinoma (HCC) is often associated with patients' poor prognosis. Our previous study has shown that resminostat, a novel HDAC inhibitor (HDACi), activated mitochondrial permeability transition pore (mPTP)-dependent apoptosis pathway in HCC cells. Here we explored the potential resminostat resistance factor by focusing on mammalian target of rapamycin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzamides
Share to Drug Synergism
Share to Hep G2 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydroxamic Acids

Share to Mitochondrial Membrane Transport Proteins

Share to Morpholines

Share to Sulfonamides

Share to TOR Serine-Threonine Kinases

Source

Identifiers

PMID: 27311860
DOI: 10.1016/j.bbrc.2016.06.060

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

mTOR inhibition sensitizes human hepatocellular carcinoma cells to resminostat.PMID 27311860Read ↗

SIRT1 silencing promotes EMT and Crizotinib resistance by regulating autophagy through AMPK/mTOR/S6K signaling pathway in EML4-ALK L1196M and EML4-ALK G1202R mutant non-small cell lung cancer cells.Semantic proximity Read ↗

Sclareolide enhances gemcitabine‑induced cell death through mediating the NICD and Gli1 pathways in gemcitabine‑resistant human pancreatic cancer.Semantic proximity Read ↗

Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1/JNK signaling pathwaySemantic proximity Read ↗

Identification of mTOR as a primary resistance factor of the IAP antagonist AT406 in hepatocellular carcinoma cells.Semantic proximity Read ↗

Catalytic mTOR inhibitors can overcome intrinsic and acquired resistance to allosteric mTOR inhibitors.Semantic proximity Read ↗

Vorinostat-induced autophagy switches from a death-promoting to a cytoprotective signal to drive acquired resistanceSemantic proximity Read ↗

The antihistamine deptropine induces hepatoma cell death through blocking autophagosome-lysosome fusionSemantic proximity Read ↗

Combination of Matrine and Sorafenib Decreases the Aggressive Phenotypes of Hepatocellular Carcinoma Cells.Semantic proximity Read ↗

Mechanisms of resistance to rapamycins.Semantic proximity Read ↗

C-Myc-dependent repression of two oncogenic miRNA clusters contributes to triptolide-induced cell death in hepatocellular carcinoma cellsSemantic proximity Read ↗

mTOR inhibition sensitizes ONC201-induced anti-colorectal cancer cell activity.Semantic proximity Read ↗

MHY2251, a New SIRT1 Inhibitor, Induces Apoptosis via JNK/p53 Pathway in HCT116 Human Colorectal Cancer CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.