Article
Brown adipose tissue harbors a distinct sub-population of regulatory T cells.
PloS one - 1 Jan 2015
Medrikova Dasa, Sijmonsma Tjeerd P, Sowodniok Katharina, Richards David M, Delacher Michael, Sticht Carsten, Gretz Norbert, Schafmeier Tobias, Feuerer Markus, Herzig Stephan
Abstract excerpt
Regulatory T (Treg) cells are critical determinants of both immune responses and metabolic control. Here we show that systemic ablation of Treg cells compromised the adaptation of whole-body energy expenditure to cold exposure, correlating with impairment in thermogenic marker gene expression and massive invasion of pro-inflammatory macrophages in brown adipose tissue (BAT). Indeed, BAT harbored a unique sub-set...
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