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Article

Deconstructing cold-induced brown adipocyte neogenesis in mice

18 Jul 2022

Abstract excerpt

Cold exposure triggers neogenesis in classic interscapular brown adipose tissue (iBAT) that involves activation of β1-adrenergic receptors, proliferation of PDGFRA+ adipose tissue stromal cells (ASCs), and recruitment of immune cells whose phenotypes are presently unknown. Single-cell RNA-sequencing (scRNA-seq) in mice identified three ASC subpopulations that occupied distinct tissue locations. Of these,...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 35848799
DOI: 10.7554/elife.80167

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