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Article

High neuropeptide Y release associates with Ewing sarcoma bone dissemination - in vivo model of site-specific metastases.

Oncotarget - 30 Mar 2015

Hong Sung-Hyeok, Tilan Jason U, Galli Susana, Izycka-Swieszewska Ewa, Polk Taylor, Horton Meredith, Mahajan Akanksha, Christian David, Jenkins Shari, Acree Rachel, Connors Katherine, Ledo Phuong, Lu Congyi, Lee Yi-Chien, Rodriguez Olga, Toretsky Jeffrey A, Albanese Chris, Kitlinska Joanna

Abstract excerpt

Ewing sarcoma (ES) develops in bones or soft tissues of children and adolescents. The presence of bone metastases is one of the most adverse prognostic factors, yet the mechanisms governing their formation remain unclear. As a transcriptional target of EWS-FLI1, the fusion protein driving ES tran...

Read the complete abstract on PubMed

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Share to Bone Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia

Share to Neuropeptide Y

Share to Oncogene Proteins, Fusion

Share to Proto-Oncogene Protein c-fli-1

Share to RNA-Binding Protein EWS

Share to Sarcoma, Ewing

Source

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Identifiers

PMID: 25714031
DOI: 10.18632/oncotarget.3345
PMCID: PMC4466675

Genes

NPY
FLI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25714031-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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