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Roux-En Y Gastric Bypass Surgery Induces Genome-Wide Promoter-Specific Changes in DNA Methylation in Whole Blood of Obese Patients

24 Feb 2015

Abstract excerpt

CONTEXT: DNA methylation has been proposed to play a critical role in many cellular and biological processes. OBJECTIVE: To examine the influence of Roux-en-Y gastric bypass (RYGB) surgery on genome-wide promoter-specific DNA methylation in obese patients. Promoters are involved in the initiation and regulation of gene transcription. METHODS: Promoter-specific DNA methylation in whole blood was measured in 11...

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PMID: 25710379
DOI: 10.1371/journal.pone.0115186

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