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Robust strand exchange reactions for the sequence-specific, real-time detection of nucleic acid amplicons.

Analytical chemistry - 17 Mar 2015

Jiang Yu Sherry, Bhadra Sanchita, Li Bingling, Wu Yuefeng Rose, Milligan John N, Ellington Andrew D

Abstract excerpt

Loop-mediated isothermal amplification (LAMP) of DNA is a powerful isothermal nucleic acid amplification method that can generate upward of 10(9) copies from less than 100 copies of template DNA within an hour. Unfortunately, although the amplification reactions are extremely powerful, real-time and specific detection of LAMP products remains analytically challenging. In order to both improve the specificity of...

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PMID: 25708458
DOI: 10.1021/ac504387c

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BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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