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Article

Chronic nicotine exposure mediates resistance to EGFR-TKI in EGFR-mutated lung cancer via an EGFR signal.

Lung cancer (Amsterdam, Netherlands) - 1 Apr 2015

Togashi Yosuke, Hayashi Hidetoshi, Okamoto Kunio, Fumita Soichi, Terashima Masato, de Velasco Marco A, Sakai Kazuko, Fujita Yoshihiko, Tomida Shuta, Nakagawa Kazuhiko, Nishio Kazuto

Abstract excerpt

BACKGROUND: Some of patients with non-small cell lung cancer (NSCLC) harboring somatic activating mutations of the epidermal growth factor receptor gene (EGFR mutations) show poor responses to EGFR-tyrosine kinase inhibitors (EGFR-TKIs) treatment. Cigarette smoking is the strongest documented risk factor for the development of lung cancer. Nicotine, while not carcinogenic by itself, has been shown to induce...

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Identifiers

PMID: 25704955
DOI: 10.1016/j.lungcan.2015.01.027

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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