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Article

Association of angiotensin-converting enzyme gene polymorphism with schizophrenia and depressive symptom severity in a Chinese population.

Human psychopharmacology - 1 Mar 2015

Hui Li, Wu Jing Qin, Ye Min Jie, Zheng Ke, He Jin Cai, Zhang Xuan, Liu Jia Hong, Tian Hai Jia, Gong Ben Hong, Chen Da Chun, Lv Meng Han, Soares Jair C, Zhang Xiang Yang

Abstract excerpt

BACKGROUND: Depressive symptoms are frequently observed in schizophrenia patients. Angiotensin-converting enzyme (ACE), a key enzyme of renin-angiotensin system, can catalyze the degradation of neuropeptides and modulate dopaminergic and serotonergic neurotransmission. Previous studies have revealed the association of the ACE gene insertion/deletion polymorphism with depressive disorder and its treatment response...

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Source

Identifiers

PMID: 25694211
DOI: 10.1002/hup.2460

Genes

ACE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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