Article
Insertion/deletion polymorphism of the angiotensin-converting enzyme gene is associated with schizophrenia in a Spanish population.
Psychiatry research - 30 Jan 2009
Crescenti Anna, Gassó Patricia, Mas Sergi, Abellana Rosa, Deulofeu Ramon, Parellada Eduard, Bernardo Miquel, Lafuente Amalia
Abstract excerpt
A number of factors make the angiotensin-converting enzyme (ACE) a candidate gene for psychiatric disorders, including its action on neurotransmitters such as dopamine. An insertion/deletion (I/D) polymorphism in an ACE gene intron is associated with ACE levels. Here we examine whether the ACE I/D polymorphism is a risk factor for schizophrenia. Participants comprised 243 subjects diagnosed with schizophrenia and...
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