Article
Comparison of Nonlinear Mixed Effects Models and Noncompartmental Approaches in Detecting Pharmacogenetic Covariates.
The AAPS journal - 1 May 2015
Tessier Adrien, Bertrand Julie, Chenel Marylore, Comets Emmanuelle
Abstract excerpt
Genetic data is now collected in many clinical trials, especially in population pharmacokinetic studies. There is no consensus on methods to test the association between pharmacokinetics and genetic covariates. We performed a simulation study inspired by real clinical trials, using the pharmacokinetics (PK) of a compound under development having a nonlinear bioavailability along with genotypes for 176 single...
Topics
- Area Under Curve
- Biological Availability
- Computer Simulation
- False Negative Reactions
- False Positive Reactions
- Genotype
- Humans
- Models, Biological
- Nonlinear Dynamics
- Pharmacogenetics
- Pharmacokinetics
- Phenotype
- Polymorphism, Single Nucleotide
- Probability