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Article

Pharmacogenetics and population pharmacokinetics: impact of the design on three tests using the SAEM algorithm.

Journal of pharmacokinetics and pharmacodynamics - 1 Aug 2009

Bertrand Julie, Comets Emmanuelle, Laffont Céline M, Chenel Marylore, Mentré France

Abstract excerpt

Pharmacogenetics is now widely investigated and health institutions acknowledge its place in clinical pharmacokinetics. Our objective is to assess through a simulation study, the impact of design on the statistical performances of three different tests used for analysis of pharmacogenetic information with nonlinear mixed effects models: (i) an ANOVA to test the relationship between the empirical Bayes estimates...

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Identifiers

PMID: 19562469
DOI: 10.1007/s10928-009-9124-x
PMCID: PMC3192406

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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