Article
Design of pharmacokinetic studies for latent covariates.
Journal of pharmacokinetics and pharmacodynamics - 1 Feb 2012
Lagishetty Chakradhar V, Coulter Carolyn V, Duffull Stephen B
Abstract excerpt
Latent covariates are covariates that are known to exist but are either observable but unavailable or unobservable at the time of the clinical study. Designs to account for latent covariates must incorporate both uncertainty in the prevalence of the covariate and the data-type of the covariate. The informativeness of the covariate will then depend on whether the covariate data is continuous, ordinal or nominal....
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