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Article

Evolution of Factor V Leiden

1 Jan 2013

Abstract excerpt

Factor V Leiden is a procoagulant mutation associated with venous and arterial thrombosis and pregnancy complications. Its high prevalence of 5% in Caucasians suggests that there are evolutionary benefits as well. Carriers are indeed reported to have various advantageous phenotypes related to haemostasis, inflammation and fertility: less acute blood loss; less menstrual blood loss; decreased risk of intracranial...

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Identifiers

PMID: 23615810
DOI: 10.1160/th13-02-0115

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