Article
Structural basis for PPARγ transactivation by endocrine-disrupting organotin compounds.
Scientific reports - 17 Feb 2015
Harada Shusaku, Hiromori Youhei, Nakamura Shota, Kawahara Kazuki, Fukakusa Shunsuke, Maruno Takahiro, Noda Masanori, Uchiyama Susumu, Fukui Kiichi, Nishikawa Jun-ichi, Nagase Hisamitsu, Kobayashi Yuji, Yoshida Takuya, Ohkubo Tadayasu, Nakanishi Tsuyoshi
Abstract excerpt
Organotin compounds such as triphenyltin (TPT) and tributyltin (TBT) act as endocrine disruptors through the peroxisome proliferator-activated receptor γ (PPARγ) signaling pathway. We recently found that TPT is a particularly strong agonist of PPARγ. To elucidate the mechanism underlying organotin-dependent PPARγ activation, we here analyzed the interactions of PPARγ ligand-binding domain (LBD) with TPT and TBT...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.