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Article

Bisphenol A derivatives act as novel coactivator-binding inhibitors for estrogen receptor β.

The Journal of biological chemistry - 1 Nov 2021

Iwamoto Masaki, Masuya Takahiro, Hosose Mari, Tagawa Koki, Ishibashi Tomoka, Suyama Keitaro, Nose Takeru, Yoshihara Eiji, Downes Michael, Evans Ronald M, Matsushima Ayami

Abstract excerpt

Bisphenol A and its derivatives are recognized as endocrine disruptors based on their complex effects on estrogen receptor (ER) signaling. While the effects of bisphenol derivatives on ERα have been thoroughly evaluated, how these chemicals affect ERβ signaling is less well understood. Herein, we sought to identify novel ERβ ligands using a radioligand competitive binding assay to screen a chemical library of...

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Identifiers

PMID: 34499926
DOI: 10.1016/j.jbc.2021.101173
PMCID: PMC8551653

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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