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Article

Coordinated regulation by two VPS9 domain-containing guanine nucleotide exchange factors in small GTPase Rab5 signaling pathways in fission yeast.

Biochemical and biophysical research communications - 20 Mar 2015

Tsukamoto Yuta, Kagiwada Satoshi, Shimazu Sayuri, Takegawa Kaoru, Noguchi Tetsuko, Miyamoto Masaaki

Abstract excerpt

The small GTPase Rab5 is reported to regulate various cellular functions, such as vesicular transport and endocytosis. VPS9 domain-containing proteins are thought to activate Rab5(s) by their guanine-nucleotide exchange activities. Numerous VPS9 proteins have been identified and are structurally conserved from yeast to mammalian cells. However, the functional relationships among VPS9 proteins in cells remain...

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Identifiers

PMID: 25686494
DOI: 10.1016/j.bbrc.2015.02.031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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