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Article

[Abnormal activation of tyrosine kinases and its role in the pathogenesis of hematological malignancies - review].

Zhongguo shi yan xue ye xue za zhi - 1 Jun 2007

Sun Xue-Mei

Abstract excerpt

Protein tyrosine kinases are key participants in signal transduction pathways that regulate cellular growth, activation and differentiation. Aberrant PTK activity resulting from gene mutation (often accompanying chromosome translocation) or overexpression of these enzymes plays an etiologic role in several clonal hematopoietic malignancies. Other than the causative effect of PTK product of the bcr/abl fusion gene...

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Share to Chromosome Aberrations
Share to Chromosomes, Human, Pair 22
Share to Chromosomes, Human, Pair 9

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to FLT3 gene

Share to Hematologic Neoplasms

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

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Source

Identifiers

PMID: 17605888

Genes

FLT3
JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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