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Article

Genetically induced impairment of retinal ganglion cells at the axonal level is linked to extrastriate cortical plasticity.

Brain structure & function - 1 Apr 2016

Mateus Catarina, d'Almeida Otília C, Reis Aldina, Silva Eduardo, Castelo-Branco Miguel

Abstract excerpt

Leber hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disorder, which leads to initially silent visual loss due to retinal ganglion cell (RGC) degeneration. We aimed to establish a link between features of retinal progressive impairment and putative cortical changes in a cohort of 15 asymptomatic patients harboring the 11778G>A mutation with preserved visual acuity and normal ocular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25680704
DOI: 10.1007/s00429-015-1002-2

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