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Article

Retinal nerve fiber layer thickness variability in Leber hereditary optic neuropathy carriers.

European journal of ophthalmology - 1 Jan 2000

Barboni Piero, Savini Giacomo, Feuer William J, Budenz Donald L, Carbonelli Michele, Chicani Filipe, Ramos Carolina Do V F, Salomao Solange R, Negri Annamaria De, Parisi Vincenzo, Carelli Valerio, Sadun Alfredo A

Abstract excerpt

PURPOSE: Recent investigations suggested that unaffected carriers of Leber hereditary optic neuropathy (LHON) may show subclinical visual alterations. Structural changes have also been detected by optical coherence tomography (OCT), which revealed a temporal thickening of the retinal nerve fiber layer (RNFL). These changes may reflect compensatory effects such as mitochondria accumulation within the RNFL axons....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22562299
DOI: 10.5301/ejo.5000154

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