Article
Genetic polymorphisms of GSTP1, XRCC1, XPC and ERCC1: prediction of clinical outcome of platinum-based chemotherapy in advanced non-small cell lung cancer patients of Bangladesh.
Molecular biology reports - 1 Sept 2020
Bushra Most Umme, Rivu Sanzana Fareen, Sifat Ali Ehsan, Nahid Noor Ahmed, Ahmed Maizbha Uddin, Al-Mamun Mir Md Abdullah, Apu Mohd Nazmul Hasan, Islam Md Siddiqul, Islam Md Reazul, Islam Mohammad Safiqul, Hasnat Abul
Abstract excerpt
Inter-individual genetic makeup can trigger variability in platinum-based chemotherapeutic responses and corresponding adverse drug reactions and toxicities. Exploring the genetic causes behind these inter-individual variabilities in platinum-based chemotherapeutic responses by investigating the effects of GSTP1 (rs1695), XRCC1 (rs25487), XPC (rs2228001) and ERCC1 (rs11615) genetic polymorphisms on toxicity and...
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