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Article

Abacavir-reactive memory T cells are present in drug naïve individuals.

PloS one - 1 Jan 2015

Lucas Andrew, Lucas Michaela, Strhyn Anette, Keane Niamh M, McKinnon Elizabeth, Pavlos Rebecca, Moran Ellen M, Meyer-Pannwitt Viola, Gaudieri Silvana, D'Orsogna Lloyd, Kalams Spyros, Ostrov David A, Buus Søren, Peters Bjoern, Mallal Simon, Phillips Elizabeth

Abstract excerpt

BACKGROUND: Fifty-five percent of individuals with HLA-B*57:01 exposed to the antiretroviral drug abacavir develop a hypersensitivity reaction (HSR) that has been attributed to naïve T-cell responses to neo-antigen generated by the drug. Immunologically confirmed abacavir HSR can manifest clinically in less than 48 hours following first exposure suggesting that, at least in some cases, abacavir HSR is due to...

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Identifiers

PMID: 25674793
DOI: 10.1371/journal.pone.0117160
PMCID: PMC4326126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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