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Article

New genetic predictors for abacavir tolerance in HLA-B*57:01 positive individuals.

Human immunology - 1 Jun 2020

Pavlos Rebecca, Deshpande Pooja, Chopra Abha, Leary Shay, Strautins Kaija, Nolan David, Thorborn Daren, Shaefer Mark, Rauch Andri, Dunn David, Montaner Julio, Rachlis Anita, Almeida Coral-Ann, Choo Linda, James Ian, Redwood Alec J, Li Yueran, Gaudieri Silvana, Mallal Simon A, Phillips Elizabeth J

Abstract excerpt

Abacavir hypersensitivity syndrome (ABC HSS) is strongly associated with carriage of human leukocyte antigen (HLA)-B*57:01, which has a 100% negative predictive value for the development of ABC HSS. However, 45% of individuals who carry HLA-B*57:01 can tolerate ABC. We investigated immune and non-immune related genes in ABC HSS (n = 95) and ABC tolerant (n = 43) HLA-B*57:01 + patients to determine other factors...

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Identifiers

PMID: 32173028
DOI: 10.1016/j.humimm.2020.02.011
PMCID: PMC7266722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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