Article
Influence of a single nucleotide polymorphism at the main ribavirin transporter gene on the rapid virological response to pegylated interferon-ribavirin therapy in patients with chronic hepatitis C virus infection.
The Journal of infectious diseases - 15 Oct 2010
Morello Judit, Cuenca Lorena, Soriano Vincent, Medrano José, Madejón Antonio, Vispo Eugenia, Barreiro Pablo, Labarga Pablo, Jiménez-Nácher Inmaculada, Rodríguez-Nóvoa Sonia
Abstract excerpt
The equilibrative nucleoside transporter 1 (ENT1) is the main protein involved in ribavirin cellular uptake. Polymorphisms at the ENT1 gene may influence ribavirin activity as part of hepatitis C virus (HCV) therapy. A retrospective study was conducted in 109 human immunodeficiency virus (HIV)-infected patients who were infected with HCV genotypes 1 or 4 who had received pegylated interferon (pegIFN)-ribavirin....
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