Article
PIK3R1 negatively regulates the epithelial-mesenchymal transition and stem-like phenotype of renal cancer cells through the AKT/GSK3β/CTNNB1 signaling pathway.
Scientific reports - 11 Mar 2015
Lin Youcheng, Yang Zhao, Xu Abai, Dong Pei, Huang Yi, Liu Huan, Li Feida, Wang Haifeng, Xu Qian, Wang Yongqiang, Sun Da, Zou Yong, Zou Xiaowen, Wang Yu, Zhang Duo, Liu Hongjie, Wu Xun, Zhang Meng, Fu Yu, Cai Zhiming, Liu Chunxiao, Wu Song
Abstract excerpt
The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway has been identified as an important pathway in renal cell carcinoma (RCC). We have reported a nonsense mutation in PIK3R1, which encodes the regulatory subunit of PI3K, in a metastatic RCC (mRCC), while the mutation was absent in the corresponding primary RCC (pRCC). To identify the function of PIK3R1 in RCC, we examined its expression in normal...
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