A common genetic variation of melanoma inhibitory activity-2 labels a subtype of pancreatic adenocarcinoma with high endoplasmic reticulum stress levels.

doi:10.1038/srep08109

Article

A common genetic variation of melanoma inhibitory activity-2 labels a subtype of pancreatic adenocarcinoma with high endoplasmic reticulum stress levels.

Scientific reports - 6 Feb 2015

Kong Bo, Wu Weiwei, Valkovska Nataliya, Jäger Carsten, Hong Xin, Nitsche Ulrich, Friess Helmut, Esposito Irene, Erkan Mert, Kleeff Jörg, Michalski Christoph W

Abstract excerpt

HNF1 homeobox A (HNF1A)-mediated gene expression constitutes an essential component of the secretory pathway in the exocrine pancreas. Melanoma inhibitory activity 2 (MIA2), a protein facilitating protein secretion, is an HNF1A target. Protein secretion is precisely coordinated by the endoplasmic reticulum (ER) stress/unfolded protein response (UPR) system. Here, we demonstrate that HNFA and MIA2 are expressed in...

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