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Article

Maternal risk for down syndrome and polymorphisms in the promoter region of the DNMT3B gene: a case-control study.

Birth defects research. Part A, Clinical and molecular teratology - 1 Apr 2015

Jaiswal Sushil Kumar, Sukla Krishna Kishore, Kumari Neha, Lakhotia Anjali Rani, Kumar Ashok, Rai Amit Kumar

Abstract excerpt

BACKGROUND: Epigenetic changes leading to improper methylation of the pericentromeric region of chromosome 21 may contribute to the nondisjunction of this chromosome. Polymorphisms in the DNA Methyltransferase 3B (DNMT3B) gene, one of the crucial gene of the folate metabolism, affects the activity of the enzyme and increases the susceptibility of nondisjunction in mothers of Down syndrome children (MDS). METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25656965
DOI: 10.1002/bdra.23348

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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