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A Clostridium difficile Lineage Endemic to Costa Rican Hospitals Is Multidrug Resistant by Acquisition of Chromosomal Mutations and Novel Mobile Genetic Elements.

Antimicrobial agents and chemotherapy - 1 Apr 2017

Ramírez-Vargas Gabriel, Quesada-Gómez Carlos, Acuña-Amador Luis, López-Ureña Diana, Murillo Tatiana, Del Mar Gamboa-Coronado María, Chaves-Olarte Esteban, Thomson Nicholas, Rodríguez-Cavallini Evelyn, Rodríguez César

Abstract excerpt

The antimicrobial resistance (AMR) rates and levels recorded for Clostridium difficile are on the rise. This study reports the nature, levels, diversity, and genomic context of the antimicrobial resistance of human C. difficile isolates of the NAPCR1/RT012/ST54 genotype, which caused an outbreak in 2009 and is endemic in Costa Rican hospitals. To this end, we determined the susceptibilities of 38 NAPCR1 isolates...

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Identifiers

PMID: 28137804
DOI: 10.1128/AAC.02054-16
PMCID: PMC5365686

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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