Mutant Neurogenin-3 in Congenital Malabsorptive Diarrhea

Abstract excerpt

BACKGROUND: Neurogenin-3 (NEUROG3) is expressed in endocrine progenitor cells and is required for endocrine-cell development in the pancreas and intestine. The NEUROG3 gene (NEUROG3) is therefore a candidate for the cause of a newly discovered autosomal recessive disorder characterized by generalized malabsorption and a paucity of enteroendocrine cells. METHODS: We screened genomic DNA from three unrelated...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Congenital gastrointestinal and neural anomalies
• Share to Gastrointestinal motility and disorders
• Share to Glycogen Storage Diseases and Myoclonus