Cognitive profile of LRRK2-related Parkinson's disease.

doi:10.1002/mds.26161

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Article

Cognitive profile of LRRK2-related Parkinson's disease.

Movement disorders : official journal of the Movement Disorder Society - 15 Apr 2015

Srivatsal Sindhu, Cholerton Brenna, Leverenz James B, Wszolek Zbigniew K, Uitti Ryan J, Dickson Dennis W, Weintraub Daniel, Trojanowski John Q, Van Deerlin Vivianna M, Quinn Joseph F, Chung Kathryn A, Peterson Amie L, Factor Stewart A, Wood-Siverio Cathy, Goldman Jennifer G, Stebbins Glenn T, Bernard Bryan, Ritz Beate, Rausch Rebecca, Espay Alberto J, Revilla Fredy J, Devoto Johnna, Rosenthal Liana S, Dawson Ted M, Albert Marilyn S, Mata Ignacio F, Hu Shu-Ching, Montine Kathleen S, Johnson Catherine, Montine Thomas J, Edwards Karen L, Zhang Jing, Zabetian Cyrus P

Abstract excerpt

BACKGROUND: Increasing evidence suggests that genetic factors play a role in the variability associated with cognitive performance in Parkinson's disease (PD). Mutations in the LRRK2 gene are the most common cause of monogenic PD; however, the cognitive profile of LRRK2-related PD is not well-characterized. METHODS: A cohort of 1,447 PD patients enrolled in the PD Cognitive Genetics Consortium was screened for...

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PMID: 25650144
DOI: 10.1002/mds.26161
PMCID: PMC4397146

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