Article
Lack of association between LRRK2 G2385R and cognitive dysfunction in Korean patients with Parkinson's disease.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia - 1 Feb 2017
Hong Jeong Hoon, Kim Yue Kyung, Park Jae Seol, Lee Ji Eun, Oh Mi Sun, Chung Eun Joo, Kim Jeong-Yeon, Sung Young-Hee, Lyoo Chul Hyoung, Lee Jae Hyeok, Kwon Do-Young, Kim Hyun Sook, Shin Hae-Won, Park Sun Ah, Park In-Seok, Kim Joong-Seok, Lee Phil Hyu, Koh Seong-Beom, Baik Jong Sam, Kim Sang Jin, Ma Hyeo-Il, Kim Jae Woo, Kim Yun Joong
Abstract excerpt
Aside from the glucocerebrosidase gene, the genetic risk factors for cognitive decline in Parkinson's disease (PD) are controversial. We investigated whether the G2385R polymorphism in leucine-rich repeat kinase 2 gene (LRRK2), a risk variant for the development of PD in East Asians, is associated with cognitive dysfunction in PD. We recruited 299 PD patients, consisting of 23 carriers and 276 non-carriers of...
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