Article
A functional brain-derived neurotrophic factor (BDNF) gene variant increases the risk of moderate-to-severe allergic rhinitis.
The Journal of allergy and clinical immunology - 1 Jun 2015
Jin Peng, Andiappan Anand Kumar, Quek Jia Min, Lee Bernett, Au Bijin, Sio Yang Yie, Irwanto Astrid, Schurmann Claudia, Grabe Hans Jörgen, Suri Bani Kaur, Matta Sri Anusha, Westra Harm-Jan, Franke Lude, Esko Tonu, Sun Liangdan, Zhang Xuejun, Liu Hong, Zhang Furen, Larbi Anis, Xu Xin, Poidinger Michael, Liu Jianjun, Chew Fook Tim, Rotzschke Olaf, Shi Li, Wang De Yun
Abstract excerpt
BACKGROUND: Brain-derived neurotrophic factor (BDNF) is a secretory protein that has been implicated in the pathogenesis of allergic rhinitis (AR), atopic asthma, and eczema, but it is currently unknown whether BDNF polymorphisms influence susceptibility to moderate-to-severe AR. OBJECTIVE: We sought to identify disease associations and the functional effect of BDNF genetic variants in patients with...
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