Article
Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic families.
International archives of allergy and immunology - 1 Jan 2009
Szczepankiewicz Aleksandra, Rose-Zerilli Matthew J, Barton Sheila J, Holgate Stephen T, Holloway John W
Abstract excerpt
BACKGROUND: A role for neuronal modulation of inflammation and airway hyper-responsiveness has been well described in asthma, and neurotrophins provide the link between inflammation and neuronal dysfunction. Brain-derived neurotrophic factor (BDNF) is an important mediator in this interaction. The aim of this study was to analyze the possible relationship between polymorphisms of the gene encoding BDNF and...
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